Mum's Plea After Teen Was Denied Cancer Drugs

By Liz Lane, Sky Reporter

The family of a teenage girl who died from a rare form of bone cancer is calling for the relaxation of rules governing who is eligible to take part in potentially life-saving drugs trials.

Despite the pleas of her parents, doctors and politicians, Chloe Drury was refused access to treatment being trialled by American pharmaceutical company BioMarin.

Her family says she was told last September, when she was 17, that she was too young to take part, and that her participation could "jeopardise [her] safety and the integrity of the trial data".

Chloe, from Purley in Surrey, died in February, a month after her 18th birthday. She had finally been allowed on the course to treat her Ewing's Sarcoma, but the cancer had progressed aggressively and it was too late.

Her mother, Debbie Binner, says she felt totally impotent.

Chloe's mum, Debbie, wants age restrictions for drugs trials to be lifted

"We were just sitting there watching our beautiful 17-year-old daughter get weaker and weaker, knowing there is something out there she could have had and it just seems totally wrong to me, and not a world that I want to live in that treats young people like that."

BioMarin said in a statement: "Our deepest sympathy goes out to the parents who are grieving the loss of their child. It is precisely because of patients who suffer from devastating rare genetic diseases that BioMarin develops therapies where there are few, if any, options.

"Ewings Sarcoma is a terrible, aggressive disease, and we hope to make a difference in this type of outcome. We are conducting a Phase 1/2 trial in several genetically defined cancers. Not only is this an early stage trial, but it is the first clinical trial that we have ever done with this therapy. It is premature to know if it is safe or effective."

The family wants age restrictions for clinical trials to be lifted. Currently fewer than 20% of 15 to 24-year-olds who have cancer are on one.

Cancer Research UK's clinical research director Kate Law admits the criteria, which sometimes stop teenagers taking part, are not always logical.

Chloe seen meeting Prince William and the Duchess Of Cambridge

"Actually for many trials I think there is no good reason. They could either go down, and join the children's trial, or they could go up and join an adult trial. And in fact the committee that I'm responsible for specifically looks at the age range for each new application. So I think we've taken on board some of the concerns that pre-dated even this sad case."

Concerns about the potential compromising of the integrity of a trial is one of the reasons drugs companies are reluctant to bend the rules, as is the fear of being sued if something goes wrong.

Les Halpin, from Tetbury in Gloucestershire, who suffers from motor neurone disease, wants experimental drugs to be available in return for terminally ill patients giving up the right to take legal action if they experience side effects.

He believes such a move would benefit not just the patient.

"The numbers of trials are very low because of the cost of having them and the current regulations put a lot of risk into drug trials which will slow the whole process down. The protocol will allow willing patients to force the pace of drug discovery and bring it much more in line with the pace of technological science."

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Police 'Taser Fireball' Death Investigation

A man who had covered himself in petrol became a human fireball after police shot him with a Taser.

A police watchdog will investigate whether firing the weapon at Andrew Pimlott, 32, caused fatal burns.

Mr Pimlott suffered serious injuries in the incident in on the evening of April 18.

He was taken to hospital and subsequently transferred to the specialist burns unit at Frenchay Hospital in Bristol where he died five days later.

The Independent Police Complaints Commission (IPCC) said two Devon and Cornwall Police officers responded to a 999 call from a caller who said that Mr Pimlott was in a garden with a can of flammable liquid.

Shortly after the police arrived he sustained serious burn injuries and an ambulance was called.

An officer deployed a Taser during the incident in Honicknowle, Plymouth, the watchdog said.

IPCC Commissioner Sarah Green said: "My condolences go to Andrew's family and friends for their loss.

"This must be a very difficult time for them and we have appointed a family liaison manager who is ensuring the family are kept informed.

A Taser gun similar to that used in the fatal incident

"Our investigators have already carried out a number of actions, including interviewing the two police officers who attended the incident and ensuring relevant evidence has been secured.

"A post-mortem was carried out yesterday and further forensic analysis will be carried out.

"The IPCC had informed the coroner of our investigation and we will share our report in due course.

"Our investigation will be looking at what information was known to the officers attending the scene, the officer's rationale for discharging a Taser on a person known to be doused in flammable liquid, whether the discharge of the Taser caused the fuel to ignite and we will look at training and policies."

In separate statements, Mr Pimlott's family paid tribute.

His parents wrote: "Dear darling son Andrew, you were a fantastic son to us, you will always be in our hearts and thoughts.

"We will never forget you. Be in our heart forever and always, we send a million kisses up to heaven.

"All our love Mum and Dad. xxx"

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M62 Hen Party Crash: Bride-To-Be Named

The bride-to-be whose hen party turned to tragedy when a minibus collided with a lorry on the M62 has been named locally as Stefanie Firth.

Ms Firth and 20 other members of her hen party remain in hospital after the crash suffering a variety of injuries.

One woman died in the collision, which occurred about 11.30am on Friday. Seven of those wounded suffered serious injuries.

Among the injured is Ashleigh Warner, who posted a photograph on Facebook with Ms Firth.

Before the accident, Ms Firth's friends had posted excited comments about the upcoming hen-do.

On Friday morning, Ms Warner wrote on Facebook: "Jumping on the Liverpool status bandwagon ......... Cos I'm sooooooo excited had my tshirt on since 8 this morning:))) hope Stefanie Firth has the best time xxxx".

The group had set off from South Elmsall, near Pontefract, West Yorkshire, when their vehicle collided with a Farmfoods lorry at junction 32 of the westbound carriage of the M62.

The driver of the lorry, a local man, was arrested in connection with the incident and remains in custody, West Yorkshire Police said.

In total 21 of the women were injured in the crash, which left the minibus on its side across a carriageway and luggage strewn across the motorway.

Six air ambulances were called to the scene, and four took casualties to nearby hospitals.

Firefighters called the crash "the worst they had seen in a number of years", Dave Walton, assistant chief fire officer at West Yorkshire Fire and Rescue Service, said.

One patient, a woman in her 40s, suffered suspected serious chest injuries and was anaesthetised before being transported, while another was airlifted to hospital also with chest injuries.

An off-duty firefighter was the first person to report the accident and stayed at the scene to help, while members of the public also helped to give first aid.

Doncaster firefighter John Nichol was passing the scene of the accident as a passenger in his father's car.

Mr Nichol said: "I got out to see if I could help, and realised there was only me there.

"First I saw a lady at the back of the minibus and realised her leg was severely broken. Then I put my head through the roof and just saw a mass of bodies.

"I think there were 11 or 12 in there, with various injuries, and around five people were out of the vehicle, hobbling around.

"I tried to calm people down and, although a bystander had called 999, I called them back to say this was a major incident and that several resources and air ambulances would be needed.

"Then I got the first aid kit out of my dad's car and triaged as many as people as I could."

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London Bus Stabbing: Boy, 16, Dies

A murder investigation has been launched following the death of a 16-year-old boy who was stabbed on a bus in London.

Police were called just after 3pm on Tuesday after the boy was stabbed on the route 393 bus.

The bus was stopped at Highbury New Park, and the youngster was treated at the scene by the ambulance service.

He was taken by air ambulance to an east London hospital, where he died late on Wednesday.

His next of kin has been informed.

A post-mortem will be held in due course.

A 15-year-old boy is currently being held at a north London police station on suspicion of attempted murder.

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Nationwide Drive To Boost MMR Vaccination

By Gamal Fahnbulleh, Sky News Reporter

One million children will be targeted in a measles vaccination drive across England as an outbreak in Wales continues to grow.

The aim is to prevent measles outbreaks by vaccinating as many unvaccinated and partially vaccinated 10 to 16 year olds as possible in time for the next school year.

The number of people infected with measles in southwest Wales has shot up by 78 in just five days, taking the total who have contracted the disease to 886.

A 25-year-old father-of-one from Swansea, who had the disease, died a week ago.

Experts believe around 330,000 children aged 10 to 16 years remain unvaccinated.

Mairead Flavin is a nurse at a GP surgery in Middlesex. She has seen an increase in the number of parents getting their children vaccinated and believes the message is getting through.

Gareth Williams, who had measles, died a week ago

"It's more standard practice now. Back in the day it wasn't. You had to do a lot of convincing and had to try to encourage parents to vaccinate their children. At this moment in time I think they're very anxious to have it done."

Experts believe the rise in measles cases can be mostly attributed to the proportion of unprotected 10-16 year olds who missed out on vaccination in the late 1990s and early 2000s when concern around the discredited link between autism and the vaccine was widespread.

Professor David Salisbury, director of immunisation at the Department of Health, said: "At the moment the hotspots in particular are in the North East and North West.

"That's quite different from where the vulnerability is and the vulnerability is all over the country. London is a real risk but we must be sure that any child anywhere in the country who has not had two doses of MMR gets vaccinated."

Dr Paul Cosford, Director for Health Protection at Public Health England, said: " We believe this national framework for a catch-up programme sets out an appropriate response to the situation in England, using the range of expertise and skills across the new public health system.

"Although nationally the numbers needing catch-up vaccination is quite large, the are relatively few in each local area.

"We are confident that local teams have the resources to identify and vaccinate those children most at risk, and the NHS has sufficient vaccine to cover the approaches described in the action plan."

The most effective time to vaccinate babies, Public Health England says, is at 13 months, with a booster follow up at three to provide 95% protection. A baby under the age of 12 months can be vaccinated if he or she comes into contact with a case of measles.

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UK Economy Avoids Triple-Dip Recession

The UK economy returned to meagre - but better than forecast - growth in the first quarter of 2013, averting the prospect of a triple-dip recession.

According to the first estimate of GDP by the Office for National Statistics (ONS) there was overall growth of 0.3% in the period - driven by the service sector though construction remained in the doldrums.

A contraction in GDP would have given the UK two consecutive quarters of negative output and plunged the UK back into recession, delivering a savage political blow to the Chancellor George Osborne.

GDP had shrunk by 0.3% in the final three months of 2012 but the ONS pointed today to a recovery in services output, with the motor industry particularly strong.

It measured growth in the sector at 0.6%, driven by 1.1% growth in the wholesale and retail distribution, hotels and restaurant trades sector.

Industrial output was lifted by the biggest rise in the mining and quarrying sector since 2002 as some North Sea oil and gas platforms came back on line after repairs that had depressed production in the final quarter of 2012.

The figures also showed that the impact of the cold winter was not as bad as feared, with weather-hit trading on the high street offset by a boost in energy demand as households ramped up their heating.

However, manufacturing output remained weak at -0.3% in the period while construction contracted by 2.5%.

Mr Osborne took to Twitter to give his reaction: "Today's figures are an encouraging sign the economy is healing. Despite a tough economic backdrop, we are making progress.

"The deficit is down by a third, businesses have created over a million and a quarter new jobs and interest rates are at record lows.

"We all know there are no easy answers to problems built up over many years, and I can't promise the road ahead will always be smooth but by continuing to confront our problems head on, Britain is recovering and we are building an economy fit for the future."

The performance will relieve some of the pressure on the Chancellor to rethink his austerity policy, following recent warnings that the UK is a "crisis economy" and last week's ratings downgrade.

IMF chief economist Olivier Blanchard told Sky News last week that Mr Osborne was "playing with fire" with his economic strategy.

Business reaction to the GDP figures was largely positive with the chief economist at the Institute of Directors, Graeme Leach, saying it was a crucial time for some some news.

He said: "Despite the squeeze on real earnings and the negative impact on confidence from the euro crisis, money supply growth has picked up and with more money sloshing around there has been more growth.

"We shouldn't get too excited about 0.3% quarterly growth but it does provide relief from all the doom and gloom."

More follows...

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Weather: Britain Set For Year's Hottest Day

Spring sunshine could see parts of the UK enjoy the country's hottest weather of the year so far - before plummeting temperatures and a sudden cold snap take hold.

Large swathes of east Wales and southern and eastern England have been basking in clear skies and bright sunshine, with 20.5C (68.9F) recorded at Frittenden in Kent on Tuesday.

And while temperatures will plunge by Friday, Wednesday is expected to be the warmest day yet of 2013.

Sky News Weather Producer Joanna Robinson said: "Southeast England looks to keep the warmth over the next few days, but there will be more in the way of cloud around than on Tuesday.

"Temperatures could reach 21C (69.8F) or 22C (71.6F) in the best of the sunny spells there, which would equal the highest temperature we've seen so far in 2013, in Manston and Gravesend on April 14."

But she added that the mercury could drop below double figures in many parts of the country later in the week.

"Unfortunately, it doesn't look like the warmth will last into the weekend," she said.

"Rain will spread across south-east England on Thursday night, allowing the cooler air further north to set in.

"Friday and Saturday look to be fairly cold nationwide, with temperatures reaching a high of just 10C (50F) or 11C (51F) in the South East.

"Scotland and Northern Ireland will see temperatures around 8C (46.4F). It will feel even colder in the northerly wind and we'll also see the return of overnight frosts too.

"Spring is a changeable season so it's not unusual to see spells of warmth along with cold snaps."

Meanwhile, hay fever sufferers have received some good news as experts predicted a shorter hay fever season this summer.

Cold weather over recent months is thought to have delayed the release of silver birch and grass pollen.

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Porn: Bid To Block Sex Sites On Public WiFi

Children will be protected from seeing pornography in public WiFi areas under plans being pushed by David Cameron.

Downing Street has confirmed the Prime Minister wants a Government-backed code of conduct that blocks certain websites in places such as cafes and train stations.

The plan to impose a ban where children are likely to be present follows high-profile campaigning by children's charities for a complete block on unacceptable sites in public areas.

It would stop them accessing inappropriate web content on their smart phones or mobile computers when they are in certain locations.

David Cameron wants a new code of conduct

However, there could be logistical difficulties in defining particular WiFi spots that are child-friendly, and it is not yet clear how the restrictions would be enforced.

Internet companies could automatically restrict access, or it may be the responsibility of individual shops and other public areas to implement the ban.

Number 10 sources have also indicated that there is no timeframe in place yet for when the code will be unveiled.

Mr Cameron, speaking to The Telegraph while campaigning in the local elections, said he wanted "good, clean WiFi".

He stressed the importance of parents having confidence in public internet systems and that their children "are not going to see things they shouldn't".

Internet service providers and government officials have been discussing how to proceed for months.

John Carr, secretary of the coalition of charities behind the campaign, told The Telegraph: "We welcome any deal which is long overdue."

Wireless internet access in public places has mushroomed in recent years as technology improved and is now widely available.

Parents are able to restrict and police their children's web use while they are at home, which campaigners believe makes them more likely to access inappropriate websites when they are out.

The coalition has already backed moves to introduce other web controls.

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Briton Dies Swimming Off Holiday Island

A Briton has died after reportedly getting into difficulties in the sea off the Canary Islands.

Steve Potter was spotted face down in the water after leaving friends on the beach to go for a swim on the holiday island of Lanzarote.

He was dragged out of the water unconscious, according to reports, but he was pronounced dead after efforts to revive him failed.

The victim, said to be aged 43 and from the north of England, was at the island's Famara Beach with friends when the tragedy happened late on Saturday afternoon.

The results of a post-mortem examination have apparently been sent to a judge put in charge of a routine inquiry into the case, but have not yet been made public.

A source has been reported as saying there was nothing to suggest the case was anything other than an accident.

A Foreign Office spokesman said: "We can confirm the death of a British national in Lanzarote on April 20.

"We are providing consular assistance to the family at this difficult time."

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Millwall FA Cup Violence: Three More Arrested

Police have arrested three more men in dawn raids in connection with violence at an FA Cup semi-final between Millwall and Wigan.

The latest arrests bring the number of people detained in the case to 23, including some who have handed themselves in, police said.

Three people have been charged.

Detective Chief Inspector Andy Barnes, who is leading the investigation, said: "We expect to make further arrests.

The images of violence were seen by millions on television

"Our message is clear. Violence at football is unacceptable. If you were involved in the violence come forward and speak with us.

"We will pursue all those responsible."

The police raids happened in London

During the second half of Millwall's 2-0 loss to Wigan on April 13 around 20 Millwall fans were involved in clashes behind the goal at Wembley Stadium.

The disturbing scenes, which were witnessed by millions on television, left some fans bloodied and youngsters in tears.

The three men arrested on Tuesday, aged 21, 22 and 27, were picked up at addresses in London by officers from Operation Arrowtip, which targets football-related crime, Scotland Yard said.

In addition, a further 17 images have been released of people at the match whom police want to speak to.

Anyone with information about the violence or who recognises the people in the pictures is urged to call police on 020 8246 0076 or Crimestoppers on 0800 555111.

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