Hundreds of thousands of pounds have been donated by members of the public after at least 40 dogs were killed in a suspected arson at one of the country's largest kennels.
A 15-year-old boy has been arrested on suspicion of arson following the blaze at Manchester Dogs' Home.
Greater Manchester Police said the fire was under control.
Residents reported hearing "dogs yelping".
Twitter user @Hoyles10 said: "Big fire at Manchester Dogs Home, apparently the building has collapsed, too late for the animals by all accounts ... Heartbreaking."
A woman saves a dog from the fire. Pic: @manchesterfire Fellow user @MostonRedDevil wrote: "Manchester dogs home is on fire with all the dogs yelping."
There were reports of people risking their lives by running into the burning building to save animals.
At least 43 dogs were confirmed by police to have died, with "numerous" other animals having to be treated for injuries, the Greater Manchester force said.
Greater Manchester Fire and Rescue Service station commander Paul Duggan confirmed part of the roof of the single-storey kennels collapsed.
Outrage and shock at the blaze resulted in several fundraising campaigns being launched which have raised more than £400,000 in total.
Part of the roof of the building collapsed On its Twitter page, Manchester Dogs Home said: "Words are not enough. Thank you everyone, you have touched our hearts and surrounded us with love and we are truly grateful.
"We are overwhelmed with the offers of help, support and money. Grateful and humbled."
Anna Stansfield, manager of the home's sister facility, Cheshire Dogs' Home, described the fire as "soul destroying".
She said: "I cannot describe what we have seen tonight. It's soul destroying."
She said all the 150 dogs rescued by the fire service would be transferred to its site in Grappenhall, Warrington.
TV presenter and singer Jodie Prenger, one of the home's patrons, tweeted: "All my thoughts are with you guys. It's broke my heart to hear such sad news."
The dogs home was established in 1893. Pic: @StacyHilton The blaze provoked an angry response on social media, but police warned people not to "take matters into their own hands".
Superintendent Marcus Noden said: "We would ask if anyone was in the area and remembers seeing anything suspicious around the dogs home that they call police and tell us what they know.
"As a dog owner myself I understand that many people will feel angry and upset about what has happened, but I would ask that they let the police carry out their investigations and not take matters into their own hands."
Firefighters said 150 dogs were rescued. Pic: Manchester Fire The home has cared for more than one million dogs since it was established in 1893. It is said to care for more than 7,000 stray and unwanted dogs each year.
A spokeswoman for Battersea Dogs and Cats Home said staff were "incredibly saddened" to hear of the fire.
Police are asking for people with donations of bedding, food or bowls to take them to Central Park Police Station later, between 11.30am and 2.30pm.
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