Part of the M25 has been closed in both directions after a serious crash in which one person died.
Three people were also taken to hospital following the accident at 1.50am, Essex Police said.
The crash involved several vehicles, including lorries.
It is reported some of the vehicles crashed through the central reservation barrier and ended up on the other side of the road. A number of people were trapped in their cars.
The Highways Agency said the motorway is now closed between junctions 23 and 27 clockwise and anticlockwise between junctions 27 and 25.
It has led to long delays on the M25 and heavy traffic in the surrounding area. Chaotic scenes were reported during the morning rush hour.
Matt Abbott, a chief reporter for various local newspapers in Essex, tweeted: "Some of the worst traffic i've seen as M25 closure has huge impact on roads in W Essex. Ongar gridlocked. I'm now at standstill in Brook St."
"Nearly 3 hours on the m25 and not completed one junction!!! #essex stretch is a nightmare," tweeted Mark Nash from Brentwood.
Transport for London said traffic was particularly heavy on the A13, A127, A12, M11, A10 and the A406 North Circular Road as a result of the crash and the diversions put in place.
An Essex Police spokesman said: "Investigations are continuing and police are also working with the Highways Agency to clear the carriageways of debris so that repairs and resurfacing can be carried out.
"No definite time for the reopening of the motorway can be set yet but it is likely to remain closed throughout the morning rush hour."
On Twitter Essex Police wrote: "Please avoid M25 in Essex after fatal road traffic collision. Both carriageways shut bet J26 and J27. Likely closed for morning rush hour."
The East of England Ambulance Service, who first attended the accident near Waltham Abbey, confirmed that one person had died at the scene.
A spokeswoman said: "Unfortunately despite the best efforts of the crew, one patient sadly died at the scene.
"Three other patients with non-life threatening injuries were taken to the Princess Alexandra Hospital for further care."
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